Diabetes and Obesity Research Network (DORN)
Founded: December 2004
Membership: Active network of more than 160 researchers (clinical, laboratory, academic, etc).
Highlights
- Adoption by the Greater Manchester Research Alliance www.gmsha.nhs.uk/gmra/ in 2005
- The DORN programme made their annual R&D report to the DH in 2006 – rated strong with an increase in grant income to over £7m (it was rated strong in 2005 also)
- Host for NW Local research network for Diabetes – 2006-2009 £1.1m Department of Health, Dr Martin Gibson, Clinical Lead – Partnership between NHS and University of Liverpool and University of Manchester. The NW Diabetes LRN is hosted at Hope Hospital, Salford www.ukcrn.org.uk
- Good links with Diabetes UK and Juvenile Diabetes Research Foundation
- Network members continue to make applications to DH (two NIHR programme grants planned), MRC, charities and other funders
- DORN (Diabetes and Obesity Research Network) are investigating running joint workshops with the newly formed NW Association for the Study of Obesity www.aso.org.uk/
- Undertaken mapping of members’ expertise (with Business Development Staff faculty MHS) developing links with industrial partners
- DORN is included in the National Institutes of Health Inventory and Evaluation of Clinical Research Networks (IECRN) www.clinicalresearchnetworks.org/default.asp
- DORN registered on NHS Networks – www.networks.nhs.uk
- Manchester's work in Social BioHealth research has grown over 2006/07 in tackling child obesity. There is substantial collaboration between North west Institute for biohealth informatics (www.nibhi.org.uk) and researchers in based at Salford Hospitals Foundation Trust and Salford PCT.
- DORN workshop ‘Molecules to Metropolis’ – November 2006 – 90 delegates, charities, industry and UKCRN diabetes research network lead spoke (Prof Des Johnston – Imperial College)
- Appointment of first DORN research studentship in collaboration with industry - Takeda Pharmaceuticals
- DORN workshop – 4th December 2007. Knowsley Hall – Obesity Issues (lead Prof John
- Wilding, University of Liverpool)
- Development of a marketing and communications strategy with advice from pharmaceutical companies
- Our meeting in December 2005 attracted more than 100 researchers and focused on increased collaboration with industry, particularly the biotech and pharmaceutical sectors - we have excellent links with industry.
Promotion of DORN's activities
- DORN is included in the National Institutes of Health Inventory and Evaluation of Clinical Research Networks (IECRN) -
- DORN is registered NHS Networks
Leads
Dr Martin GibsonDirector of Research and Development, Salford Royal Hospitals NHS Trust.
Professor Mark Dunne
Faculty of Life Sciences
Workshops and meetings
Grants
- Current Grant income for members of DORN is £6.9m
- Six new multidisciplinary grant proposals were submitted as direct result of the network launch
- Successful in the bid to run the Northwest Diabetes Local Research Network, working closely with the National Diabetes Research Network. The LRN will be hosted in Hope Hospital Salford, in collaboration with Trusts across the North West and universities of Manchester and Liverpool - £1.1 million 2006-2008, Department of Health
- Diabetes UK Boulton AJM, Jude EB (PIs) 2007-2010. A randomized double-blind placebo controlled trial of the oral bisphosphonates Alendronate plus intravenous Pamidronate, in active diabetic Charcot Neuroarthropathy. £149,000.00
- National Institute of Health Research (NIHR) programme grant. Poston L (PI) 2008-2013. Improving pregnancy outcome in obese women. £1,999,978.
- National Institutes of Health (US) Boulton AJM, Malik RA (PIs) 2008-2012. Corneal confocal microscopy: a non-invasive surrogate for diabetic neuropathy. $1,285,000.
- Pfizer Paul Durrington (PI) 2004-2008. Protection against nephropathy in diabetes with atorvastatin £750,000.
Publications 2007/08
- Apelqvist J, Armstrong DG, Lavery LA, Boulton AJM. Resource utilization and economic costs of care based on a randomized trial of vacuum-assisted closure therapy in the treatment of diabetic foot wounds. Am J Surg 2008 (e-pub ahead of print).
- Canoy D, SM Boekholdt, N Wareham , R Luben, A Welch, S Bingham, Day N, and Khaw KT: Fat distribution and risk of coronary heart disease in men and women in the European Prospective Investigation Into Cancer and Nutrition in Norfolk cohort: a population-based prospective study. Circulation 2007 Dec 18;116(25):2933-43.
- Lawson,V. Bundy,C. and Harvey,N. The development of personal models of diabetes in the first 2 years after diagnosis: a prospective longitudinal study. Diabetic Medicine 2008; 25: 482-90.
- Raikou, M., McGuire, A., Colhoun, H.M., Betteridge, D.J., Durrington, P.N., Hitman, G.A., Neil, H.A.W., Livingstone, S.J., Charlton-Menys, V., Fuller, J.H. Cost effectiveness of primary prevention of CVD with atorvastatin in type 2 diabetes: results from the Collaborative Atorvastatin Diabetes, Study (CARDS). Diabetologia 2007; 50: 733-740
- Richards N, Harris K, Whitfield M, O'Donoghue D, Lewis R, Mansell M, Thomas S, Townend J, Eames M, Marcelli D: The impact of population-based identification of chronic kidney disease using estimated glomerular filtration rate (eGFR) reporting. Nephrol Dial Transplant. 2008 Feb;23(2):556-61. Epub 2007 Dec 8.
Publications 2005/06
Over 90 publications in 2005/06 by network members.
• National Institute of Health Research (NIHR) programme grant. Poston L (PI) 2008-2013. Improving pregnancy outcome in obese women. £1,999,978.• National Institute of Health Research (NIHR) programme grant. Poston L (PI) 2008-2013. Improving pregnancy outcome in obese women. £1,999,978.• National Institute of Health Research (NIHR) programme grant. Poston L (PI) 2008-2013. Improving pregnancy outcome in obese women. £1,999,978.• National Institute of Health Research (NIHR) programme grant. Poston L (PI) 2008-2013. Improving pregnancy outcome in obese women. £1,999,978.
To register your research interests with the Diabetes and Obesity Research Network, please complete and return the Research Interest Form - (word)
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